Polymer-supported copper catalysts have attained a prominent status and continue to be a focal point of ongoing research and development due to their adaptable properties, which make them invaluable tools for diverse catalytic reactions in aqueous solutions. The objective of this investigation is to develop catalysts supported on a random copolymer that can be assembled in water. A series of random copolymer was prepared through postpolymerization modification of a polymer precursor, poly(pentafluorophenyl acrylate) (PPFPA), employing 1-amino-2-propanol and 1-(3-aminopropyl)imidazole via nucleophilic substitution. Following alkylation and copper insertion, it yielded a polymer-supported copper (Cu) catalyst on poly(