Structural and Mechanistic Characterization of the Flavin-Dependent Monooxygenase and Oxidase Involved in Sorbicillinoid Biosynthesis.

• Tác giả: Nicolò Angeleri, Mark Arentshorst, Marco W Fraaije, Barbara Mannucci, Andrea Mattevi, Quoc-Thai Nguyen, Arthur F J Ram, Gwen Tjallinks, Jaap Visser
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : ACS chemical biology , 2025
• Bộ sưu tập: NCBI
• ID: 722931

Tóm tắt

Sorbicillinoids are yellow secondary metabolites synthesized through an elegant combination of enzymatic and spontaneous biochemical processes. The flavin-dependent monooxygenase SorC and oxidase SorD are crucial in this interplay, enabling the generation of a diverse array of functionally complex sorbicillinoids. By solving the crystal structures of SorC and SorD from