Expanding Diversity of Fused Steroid-Quinoline Hybrids by Sequential Amination/Annulation/Aromatization Reactions.

 0 Người đánh giá. Xếp hạng trung bình 0

Tác giả: Antonio Arcadi, Marco Chiarini, Caterina Momoli, Valerio Morlacci, Laura Palombi

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: United States : The Journal of organic chemistry , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 722936

Viable alternative approaches to a variety of ring A and ring D-fused steroid-quinoline hybrids, along with ring A, D-fused, and/or ring A-fused, side chain-substituted steroid-bis-quinolines were explored by means of sequential amination/annulation/aromatization reactions of suitable ketosteroids with 2-acyl-substituted anilines. Key factors directing the chemoselective behavior of polyfunctionalized substrates were investigated. Remarkably, the use of TMSOTf as an alternative promoter/catalyst enabled the direct synthesis of the desired hybrids, avoiding the protection/deprotection steps of the conventional procedures when the starting substrates contained labile functional groups.
Tạo bộ sưu tập với mã QR

THƯ VIỆN - TRƯỜNG ĐẠI HỌC CÔNG NGHỆ TP.HCM

ĐT: (028) 36225755 | Email: tt.thuvien@hutech.edu.vn

Copyright @2024 THƯ VIỆN HUTECH