Palladium/Norbornene Cooperative Catalysis 2-Fold C-H/C-X Coupling: Construction of Polycyclic Aromatic Hydrocarbons from Brominated Benzimidazoles.

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Tác giả: Jin-Heng Li, Yi-Ming Li, Yuan-Yuan Sun, Ming-Xuan Wang, Wen-Zhou Yu, Wei Zeng, Ming-Yao Zhang, Ze-Hui Zheng, Yan-Ping Zhu

Ngôn ngữ: eng

Ký hiệu phân loại: 133.594 Types or schools of astrology originating in or associated with a

Thông tin xuất bản: United States : Organic letters , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 723181

A palladium/norbornene (NBE)-catalyzed 2-fold C-H/C-X coupling reaction of aryl iodides is reported. Bromine-substituted benzimidazoles were chosen as electrophilic and termination reagents, and the versatile polycyclic aromatic hydrocarbon products were successfully obtained. The strategy overcomes the challenge of catalyst poisoning by heterocyclic substrates. In addition, the imidazole moiety in the product is endowed with a localization role, thus enabling the compounds to be applied in a wider synthetic scenario, and the fluorescence persisted. Furthermore, the bioactivity evaluation has identified three promising leading compounds
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