Synthesis of 2-Organoselenyl Quinolines via Electro-Oxidative Selenocyclization of Isocyanides.

• Tác giả: Jia-Le Fu, Peng-Fei Huang, Yu Liu, Zhi-Gang Quan, Ke-Wen Tang
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : The Journal of organic chemistry , 2025
• Bộ sưu tập: NCBI
• ID: 723221

Tóm tắt

Organoselenium compounds and quinolines are widely used in drugs and materials. Herein, we report an electro-oxidative cyclization between isocyanides and diselenides to effectively synthesize 2-organoselenyl quinolines in a simple undivided cell without transition-metal catalysts or toxic oxidants. Gram-scale synthesis and postsynthetic modifications highlighted the practicality of this electrochemical strategy. A series of 2-organoselenyl quinolines are produced with up to 82% yield, good functional group tolerance and high atom efficiency under room temperature.