1,1,1,3,3,3-Hexafluoroisopropanol-Promoted Synthesis of Structurally Diverse Alkylidene-4-thiazolidinones/selenazolidinones Involving an Azaoxyallyl Cation.

• Tác giả: Ankita Biswas, Subhadeep Hazra, Soumik Mondal, Manveer Patel, Jaideep Saha
• Ngôn ngữ: eng
• Ký hiệu phân loại: 133.594 Types or schools of astrology originating in or associated with a
• Thông tin xuất bản: United States : Organic letters , 2025
• Bộ sưu tập: NCBI
• ID: 723269

Tóm tắt

A one-pot process involving cycloaddition of the azaoxyallyl cation with thioamide and a synchronous E1-type elimination of the C2 amino group from the cycloadduct is disclosed, leading to diverse alkylidene-4-thiazolidinones. Amine elimination under acid-free conditions or without quaternization and forging a stereoselective olefin formation were among the interesting reactivity traits revealed through the present work. Conjugated thioamide permitted side-chain branching through a three-component process. Access to spirooxindolyl thiazolidinones and selenazolidinones adds further value to the process.