Highly elastic bioactive bR-GelMA micro-particles: synthesis and precise micro-fabrication via stop-flow lithography.

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Tác giả: Dae Kun Hwang, Basel A Khader, Christian Volpe, Stephen D Waldman

Ngôn ngữ: eng

Ký hiệu phân loại: 611.74 Connective tissues

Thông tin xuất bản: England : Biomedical materials (Bristol, England) , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 723314

Osteoporosis poses a significant public health challenge, necessitating advanced bone regeneration solutions. While gelatin methacrylate (GelMA) hydrogels show promise, conventional fabrication methods using aqueous two-phase systems (ATPS) often result in inconsistent mechanical properties and structural irregularities. This study presents an approach synthesizing new methods and parameters for bR-GelMA, utilizing stop-flow lithography (SFL) to fabricate highly elastic micro-particles incorporating bioactive glass particles. SFL, in contrast to ATPS, offers precise control over micro-particle formation, enabling the production of uniform and stable structures ideal for biomedical applications. The resulting elastic micro-particles demonstrate rapid degradation, enhanced cell proliferation, and improved mechanical strength without compromising flexibility. This innovative approach using SFL to fabricate GelMA-based micro-particles holds significant promise for bone regeneration and other critical therapeutic applications.
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