Rescue of loss-of-function long QT syndrome-associated mutations in K

0 Người đánh giá. Xếp hạng trung bình 0

Tác giả: Alicia De la Cruz, Federica Giannetti, Irene Hiniesto-Iñigo, Amaia Jauregi-Miguel, H Peter Larsson, Sara I Liin, Julien Louradour, Siri Lundholm, Katja E Odening, Nina E Ottosson, Luca Sala, Akshay Sridhar

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: England : British journal of pharmacology , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 723349

Thêm vào giỏ Liên kết toàn văn

BACKGROUND AND PURPOSE: Congenital long QT syndrome (LQTS) involves genetic mutations affecting ion channels, leading to a prolonged QT interval and increased risk of potentially lethal ventricular arrhythmias. Mutations in the genes encoding K EXPERIMENTAL APPROACH: The two-electrode voltage clamp technique on Xenopus oocytes expressing human K KEY RESULTS: ARA-S enhanced the function of all mutated channels by shifting V CONCLUSIONS AND IMPLICATIONS: This study demonstrates the rescuing capability of ARA-S on a diverse set of LQTS mutants. These insights may aid in developing drug compounds using ARA-S sites and mechanisms and guide interpretation of which LQTS mutants respond well to such compounds.

Tạo bộ sưu tập với mã QR