JNK mediates serine phosphorylation of STAT3 in response to fatty acids released by lipolysis.

• Tác giả: Ayla Melisa Aksu, Amena Akter, Pania E Bridge-Comer, Preetveer Dhillon, Oluwafemi Gbayisomore, Shannon M Reilly, Zane J Zerbel
• Ngôn ngữ: eng
• Ký hiệu phân loại: 959.3032 *Thailand
• Thông tin xuất bản: United States : Research square , 2025
• Bộ sưu tập: NCBI
• ID: 723394

Tóm tắt

Adipocytes play an essential role in energy balance and metabolic health. Excess nutrients are stored within the white adipose tissue (WAT) as triglycerides. Energetic demand is communicated to the adipocyte by the sympathetic nervous system. Catecholamines released by nerve terminals in the adipose tissue promote lipolysis, a process in which triglycerides are broken down into fatty acids and glycerol. Lipolytic activation of white adipocytes is associated with an increase in the rate of oxygen consumption. This lipolysis induced respiration requires phosphorylation of signal transducer and activator of transcription 3 (STAT3) at Ser