Physical activity and

• Tác giả: Sanjay Asthana, Barbara B Bendlin, Tobey J Betthauser, Eli G Blum, Brianne Breidenbach, Bradley Christian, Dane B Cook, Noah Cook, Ira Driscoll, Kyle J Edmunds, Sterling C Johnson, Sarah R Lose, Yue Ma, Ozioma C Okonkwo, Mark Sager
• Ngôn ngữ: eng
• Ký hiệu phân loại: 344.0412 Labor, social service, education, cultural law
• Thông tin xuất bản: United States : medRxiv : the preprint server for health sciences , 2025
• Bộ sưu tập: NCBI
• ID: 723429

Tóm tắt

 BACKGROUND: Physical activity (PA) is a protective factor against amyloid-β (Aβ) accumulation in adults at risk for Alzheimer's disease (AD). This association, however, may differ by apolipoprotein E ( MATERIALS AND METHODS: Included were 388 cognitively unimpaired, older (mean age ± SD = 68.10 ± 7.09
  66% female) participants from the Wisconsin Registry for Alzheimer's Prevention (WRAP) study. The cohort was enriched with both family history of AD at enrollment and a higher overall prevalence of RESULTS: Three-way interactions (Age × PA × CONCLUSION: Individuals with high