Local ancestry informed GWAS of warfarin dose requirement in African Americans identifies a novel CYP2C19 splice QTL.

• Tác giả: Cristina Alarcon, Larisa H Cavallari, Li Gong, Julie A Johnson, Teri E Klein, David O Meltzer, Edith A Nutescu, Travis J O'Brien, Minoli A Perera, Anmol Singh, Matthew Tuck
• Ngôn ngữ: eng
• Ký hiệu phân loại: 597.67 *Gasterosteiformes
• Thông tin xuất bản: United States : medRxiv : the preprint server for health sciences , 2025
• Bộ sưu tập: NCBI
• ID: 723433

Tóm tắt

African Americans (AAs) are underrepresented in pharmacogenomics which has led to a significant gap in knowledge. AAs are admixed and can inherit specific loci from either their African or European ancestor, known as local ancestry (LA). A previous study in AAs identified single nucleotide polymorphisms (SNPs) located in the