Zebrafish embryos as a teratogenicity screening tool to reduce potential birth defects.

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Tác giả: Lei Cai, Xueping Chen, Jinping Cheng, Zhenlie Huang, Zongyu Miao, Jinghui Peng, Erping Yan, Jing Yang

Ngôn ngữ: eng

Ký hiệu phân loại: 940.5472 1918

Thông tin xuất bản: United States : Reproductive toxicology (Elmsford, N.Y.) , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 723475

Teratogens play a crucial role in the development of birth defects, making effective screening vital for prevention and management. This study aimed to develop an optimized zebrafish embryo-based platform for teratogenicity screening and further evaluate its findings with established clinical and animal data. Zebrafish embryos [6-8 h post-fertilization (hpf)] were exposed to 19 different test solutions, including nine known teratogens and ten non-teratogens, in 96-well plates, and mortality and morphological abnormalities were assessed at 48, 72, and 96 hpf. The half-lethal concentration (LC
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