Enhancing Neuroplasticity for Post-Stroke Motor Recovery: Mechanisms, Models, and Neurotechnology.

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Tác giả: Yi-Feng Chen, Yuzhou Lin, Jingxin Wang, Yuling Wang, Wangwang Yan, Mingming Zhang

Ngôn ngữ: eng

Ký hiệu phân loại: 691.99 Adhesives and sealants

Thông tin xuất bản: United States : IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 723588

Stroke remains a significant global health challenge, imposing substantial socioeconomic burdens. Post-stroke neurorehabilitation aims to maximize functional recovery and mitigate persistent disability through effective neuromodulation, while many patients experience prolonged recovery periods with suboptimal outcomes. This review explores innovative neurotechnologies and therapeutic strategies enhancing neuroplasticity for post-stroke motor recovery, with a particular focus on the subacute and chronic phases. We examine key neuroplasticity mechanisms and rehabilitation models informing neurotechnology use, including the vicariation model, the interhemispheric competition model, and the bimodal balance-recovery model. Building on these theoretical foundations, current neurotechnologies are categorized into endogenous drivers of neuroplasticity (e.g., task-oriented training, brain-computer interfaces) and exogenous drivers (e.g., brain stimulation, muscular electrical stimulation, robot-assisted passive movement). However, most approaches lack tailored adjustments combining volitional behavior with brain neuromodulation. Given the heterogeneous effects of current neurotechnologies, we propose that future directions should focus on personalized rehabilitation strategies and closed-loop neuromodulation. These advanced approaches may provide deeper insights into neuroplasticity and potentially expand recovery possibilities for stroke patients.
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