This study investigates the application and evaluation of National Comprehensive Cancer Network (NCCN) guidelines within health education frameworks aimed at lung nodule screening. Through the integration of NCCN directives, tailored educational strategies catering to diverse demographics, and robust interdisciplinary collaboration, the research underscores the pivotal role of health education in optimizing screening efficacy and patient outcomes. Moreover, it critically analyzes the challenges encountered, offering insightful recommendations for future research and practice while avoiding replication of existing literature. This study contributes to the field with scholarly rigor, emphasizing the imperative of continuous education in improving patient care standards and mitigating the burden of lung cancer.