Autophagy in tumor immune escape and immunotherapy.

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Tác giả: Xinyuan Jiang, Yueli Shi, Peng Sun, Huan Wang, Mingshu Xiao, Zhiyong Xu, Xin Yao, Xijing Yuan

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: England : Molecular cancer , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 723792

 The immunotherapy targeting tumor immune escape mechanisms has become a critical strategy in anticancer treatment
  however, the challenge of immune resistance remains significant. Autophagy, a cellular response to various stressors, involves the degradation of damaged proteins and organelles via lysosomal pathways, maintaining cellular homeostasis. This process not only supports tumor cell survival but also profoundly impacts the efficacy of cancer immunotherapies. The modulation of autophagy in tumor cells or immune cells exerts dual effects on tumor immune escape and immunotherapy. However, the mechanistic details of how autophagy influences the immune system and therapy remain inadequately understood. Given this complexity, a deeper understanding of the role of autophagy in the tumor-immune landscape could reveal novel therapeutic avenues. By manipulating autophagy appropriately, it may be possible to overcome immune resistance and enhance the effectiveness of immunotherapeutic strategies. This article summarizes the role of autophagy in tumor immunity, its relationship with immunotherapy, and the potential therapeutic benefits of targeting autophagy to strengthen antitumor immune responses and optimize the outcomes of immunotherapy.
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