Neuroendocrine carcinoma of the cervix: the value of postoperative radiation in early-stage disease.

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Tác giả: Dongyan Cao, Ying Jin, Shuiqing Ma, Lingya Pan, Xiaochen Song, Xianjie Tan, Ming Wu, Yang Xiang, Jiaxin Yang, Hui Zhang, Sen Zhong

Ngôn ngữ: eng

Ký hiệu phân loại: 597.922 *Chelydridae (Snapping turtles)

Thông tin xuất bản: England : Annals of medicine , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 723876

OBJECTIVE: The current treatment for early-stage neuroendocrine carcinoma of the cervix (NECC) mainly relies on operation and chemotherapy. We want to evaluate values of postoperative radiation in early-stage NECC. METHODS: Retrospective cohort study. Early-stage NECC patients from 2006 to 2022 in our hospital were included and divided into Postoperative non-radiation group (Group A) and Postoperative radiation group (Group B). We use Kaplan-Meier method to analyze the progression-free survival (PFS), overall survival (OS), recurrence and OS rate. RESULTS: Sixty-six cases were included, 32 (48.5%) in Group A and 34 (51.5%) in Group B. After 35 (range 12-116) months follow-up, 26 (39.4%) had recurrence. Compared with Group A, Group B had lower pelvic recurrence rate (12.5% vs 2.9%, LIMITATIONS: Retrospective study and relative small sample size. CONCLUSIONS: Postoperative radiation seems to prolong PFS and OS in patients with cervical stromal invasion ≥1/2. LVSI was a high-risk factor for tumour recurrence, but radiation after surgery in patients with LVSI seems have no survival benefits.
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