Pharmacokinetics of Milbemycin Oxime in Pekingese Dogs after Single Oral and Intravenous Administration.

 0 Người đánh giá. Xếp hạng trung bình 0

Tác giả: Yan Dai, Ming-Hui Duan, Yang-Guang Jin, Xing-Ping Li, Ze-En Li, Yue Liu, Fan Yang, Yan-Ni Zhang

Ngôn ngữ: eng

Ký hiệu phân loại: 809.008 History and description with respect to kinds of persons

Thông tin xuất bản: England : Veterinary medicine and science , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 723900

OBJECTIVE: This study aimed to characterize the pharmacokinetic profiles of milbemycin oxime in Pekingese dogs following a single oral (PO) and intravenous (IV) dose. Six clinically healthy Pekingese dogs, with an average body weight (BW) of 4.75 kg, were included. Each dog received an IV injection of milbemycin oxime solution and PO doses of both milbemycin oxime tablets and nanoemulsion, all administered at 1 mg/kg BW. METHODS: Blood samples (∼0.6 mL) were collected at various time points, and milbemycin oxime concentrations were measured using a validated high-performance liquid chromatography (HPLC) method with ultraviolet (UV) detection. Pharmacokinetic parameters were obtained through non-compartmental analysis (NCA) using WinNonLin software. RESULTS: Oral administration of milbemycin oxime tablets resulted in a peak concentration (C CONCLUSIONS: These findings demonstrate that the milbemycin oxime nanoemulsion is absorbed more rapidly and completely, with significantly higher bioavailability than the tablet form. This suggests that the nanoemulsion could effectively overcome the issues of poor diffusion and low bioavailability associated with tablet formulations, positioning it as a promising alternative to traditional milbemycin oxime tablets.
Tạo bộ sưu tập với mã QR

THƯ VIỆN - TRƯỜNG ĐẠI HỌC CÔNG NGHỆ TP.HCM

ĐT: (028) 36225755 | Email: tt.thuvien@hutech.edu.vn

Copyright @2024 THƯ VIỆN HUTECH