Microplastics (MPs) have become a major global environmental problem due to their accelerated distribution throughout different environments. Their widespread presence is a potential threat to the ecosystems because they alter the natural interaction among their constituent elements. MPs are considered as emergent pollutants due to the huge amount existing in the environment and by the toxic effects they can cause in living beings. The removal of MPs from water bodies and wastewaters is a control strategy that needs to be implemented from the present on and strictly constantly in the near future to control and mitigate their distribution into other environments. The present work shows a detailed comparison of the current potential technologies for the remediation of the MPs pollution. That is, physical, biological, and chemical methods for the removal of MPs from water bodies and wastewaters. Focusing mainly on the discussion of the perspective on the current innovative technologies for the removal or degradation of the MPs, rather than in a deep technical discussion of the methodologies. The selected novel physical methods discussed are adsorption, ultrafiltration, dynamic membranes and flotation. The physical methods are used to modify the physical properties of the MPs particles to facilitate their removal. The biological methods for the removal of MPs are based on the use of different bacterial strains, worms, mollusks or fungus to degrade MPs particles due to the hydrocarbon chain decrease of the particles, because these kinds of microorganisms feed on these organic chains. The degradation of MPs in water bodies and wastewaters by chemical methods is focusing on coagulation, electrocoagulation, photocatalysis, and ozonation. Chemical methods achieve the degradation of MPs by the modification of the chemical structure of the particles either by the change of the surface of the particles or by attacking radicals with a high oxidation capacity. Additionally, some interesting combinations of physical, chemical, and biological methods are discussed. Finally, this work includes a critical discussion and comparison of several novel methods for the removal or degradation of MPs from water bodies and wastewaters, emphasizing the areas of opportunity and challenges to be faced.