Enhanced antibacterial efficacy of new benzothiazole phthalimide hybrid compounds/methyl-β-cyclodextrin inclusion complexes compared to the free forms: Insights into the possible mode of action.

• Tác giả: Alexia Barbarossa, Angela Buono, Alessia Carocci, Antonio Carrieri, Filomena Corbo, Roberto Grisorio, Andrea Nicola Paparella, Antonio Rosato, Gian Paolo Suranna, Adriana Trapani, Paola Vitale
• Ngôn ngữ: eng
• Thông tin xuất bản: Netherlands : International journal of pharmaceutics , 2025
• Bộ sưu tập: NCBI
• ID: 724069

Tóm tắt

With the aim to gain further insights into the possible mechanism(s) involved in the cyclodextrin (CD)-mediated enhancement of antimicrobial activity, herein we report the preparation and fully characterization of a series of phenoxy-benzothiazole-phthalimide hybrid compounds and the corresponding complexes with methyl-β-CD (Me-β-CD). Next, these complexes were tested against selected Gram positive and Gram-negative bacterial strains and the observed antibacterial activity compared to those of the free forms. Results from