A stability-indicating potentiometric platform for assaying Metoprolol succinate and felodipine in their tablets and human plasma.

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Tác giả: Maha F Abd El Ghanyd, Dina A Ahmed, Amr M Badawey, Haitham A El Fiky, Nermine V Fares, Mahmoud A Tantawy

Ngôn ngữ: eng

Ký hiệu phân loại: 294.3823 Buddhism

Thông tin xuất bản: Switzerland : BMC chemistry , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 724195

Solid contact electrodes are prevalent in analytical applications due to their superior performance compared to traditional electrodes. Nonetheless, these electrodes have been observed to develop a water layer, which compromises their stability. In this study, we introduce an innovative solid contact ion selective electrode designed to mitigate this issue by incorporating multi-walled carbon nanotubes. This system was utilized for potentiometric sensing of metoprolol and felodipine. Furthermore, molecular imprinted polymer was developed to enhance selectivity for determination of felodipine. The electrode modified with multi-walled carbon nanotubes was employed for the quantification of metoprolol, exhibiting a Nernstian slope of 55.23 mV/decade over a linear concentration range of 1.0 × 10
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