The radial artery most often arises from the brachial artery in the cubital fossa, lying deep to the brachioradialis in the upper part and superficial in the lower part. Recently, the radial artery has increasingly been used for coronary procedures. However, the radial artery is observed to vary in origin, course, and branching pattern. Precise knowledge of these parameters is essential for successful outcomes. Considering the immense clinical significance associated with this artery, this study was conducted. The aim is to expound the details of the radial artery and to highlight the associated implications, serving as a ready reference for vascular surgeons. The study was conducted using various databases and various terms related to the radial artery were used to search the literature. The literature reveals that the radial artery varies in origin, course, and branching pattern and information on these parameters will help vascular surgeons to carry out various procedures with minimum complications.