With the outbreak of Mpox in non-endemic countries in May 2022, which has captured international attention. In response, this study leveraged the real-time, predictive, and wide coverage advantages of big data to reflect the public's needs and interests regarding the Mpox epidemic, and explore its potential early warning role. We carried out a systematic data search weekly on two major network data platforms-Baidu Search Index (BDI) and WeChat Search Index (WCI) in China, and the index data overview, main concern information, hotspot regional distribution were analyzed. Besides, the correlation between the search index and the number of new cases of Mpox globally and within China were also investigated. Our results showed that both BDI and WCI mirrored the trends of the Mpox epidemic, with peaks in interest aligning with the release of relevant policies and events. The public's interest evolved from basic knowledge of the disease to a focus on treatment and prevention, with attentiveness centrally placed in economically developed areas such as Guangdong, Beijing, and Shanghai. A positive correlation was observed between the Chinese epidemic and the BDI (