[Gandou Bushen Decoction Ameliorates Cognitive Impairment in Wilson Disease Model TX Mice by Regulating Melatonin Synthesis via the SIRT3/FOXO3α Pathway].

• Tác giả: Xinru Fang, Hui Han, Zhenzhen Jiang, Qianzhuo Liu, Luyao Wang, Tingting Wang, Limin Wu, Yike Yue, Dan Zhao
• Ngôn ngữ: eng
• Ký hiệu phân loại: 133.594 Types or schools of astrology originating in or associated with a
• Thông tin xuất bản: China : Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition , 2025
• Bộ sưu tập: NCBI
• ID: 724408

Tóm tắt

OBJECTIVE: Melatonin has been shown to have neuroprotective effects. This study is aimed at observing the effects of copper deposition on cognitive function in a toxic milk (TX) mouse model of Wilson disease (WD), and investigating the effects and mechanisms of action of Gandou Bushen Decoction (GDBSD) on melatonin synthesis and pineal function in the WD model mice. METHODS: A total of 30 homozygous TX mice were randomly assigned to 3 groups ( RESULTS: Compared with the NC group, the WD group exhibited decreased learning and cognitive abilities ( CONCLUSION: GDBSD can alleviate cognitive impairments in WD mice caused by pineal gland copper deposition by inhibiting oxidative stress and apoptosis in the pineal gland. The underlying molecular mechanism is associated with the regulation of the SIRT3/FOXO3α signaling pathway.