[Preparation of Trop2-Targeted CAR-T Cells Based on Nanobodies and Their Antitumor Effects Against Non-Small Cell Lung Cancer].

0 Người đánh giá. Xếp hạng trung bình 0

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: China : Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 724429

Thêm vào giỏ Liên kết toàn văn

OBJECTIVE: To investigate whether chimeric antigen receptor (CAR) T cells constructed with nanobodies based on trophoblast cell-surface antigen 2 (Trop2) can be used to treat Trop2-positive non-small cell lung cancer. METHODS: A Trop2-specific phage display nanobody library was constructed to screen for Trop2-specific nanobodies. The antigen-binding capacities of three Trop2 nanobodies (8 RESULTS: A Trop2-specific nanobody was successfully screened from the nanobody library, and indirect ELISA initially indicated that nanobody 48 CONCLUSION: These findings demonstrate that CAR T cells constructed with Trop2 nanobodies can effectively treat Trop2-positive non-small cell lung cancer.

Tạo bộ sưu tập với mã QR