OBJECTIVE: To investigate the mechanisms by which METHODS: The Cancer Genome Atlas (TCGA) database was used to analyze the correlation between chemokine ligand 20 (CCL20), CCR6, and Treg. The Treg enrichment index and the expression levels of interleukin (IL)-10 and tumor necrosis factor β1 (TGF-β1) were assessed in the high CCR6 expression group of OSCC patients. C57BL/6 mice were randomly assigned to a control group and an experimental group ( RESULTS: Bioinformatics analysis revealed a correlation between CCL20, CCR6, and Treg (