Prevalence and Predictors of Pulmonary Hypertension in Children with Portal Hypertension: A Single Center Study.

• Tác giả: Hala Mounir Agha, Noha Ali, Ahmed Said Behairy, Nehal El Koofy, Hanan Mina Fouad, Sawsan Hassan Okasha, Rehab Hamdy Zawam
• Ngôn ngữ: eng
• Ký hiệu phân loại: 662.2 Explosives
• Thông tin xuất bản: Korea (South) : Pediatric gastroenterology, hepatology & nutrition , 2025
• Bộ sưu tập: NCBI
• ID: 724525

Tóm tắt

 PURPOSE: This study aimed to estimate the prevalence and predictors of portopulmonary hypertension (POPH) in children with portal hypertension. METHODS: We recruited children of both sexes aged 3-15 years with portal hypertension that was clinically suspected and confirmed by the presence of varices on esophagogastroduodenoscopy (EGD). The participants underwent clinical examination, 6-min walk distance (6-MWD), and echocardiography. RESULTS: We enrolled 94 children with portal hypertension: 26.6% with pre-hepatic causes and 73.4% secondary to chronic liver disease. Among our participants, 13.8% had one or more cardiac manifestations, such as exercise intolerance, dyspnea on exertion, cyanosis, or orthopnea, whereas 86.2% were asymptomatic. EGD examination revealed grade I varices in 54.3% of cases, grade II-III in 43.6%, and grade IV in 2.1%. Pulmonary hypertension (>
 35 mmHg) was detected in 30.9% of cases using echocardiography
  two of them were >
 45 mmHg. Patients with POPH had significantly more frequent dyspnea on exertion, lower O CONCLUSION: POPH was detected in 30.9% of our study group. High-grade varices and low O