BACKGROUND: Patients who experience postoperative nausea and vomiting are not happy with their surgical outcomes. Preventing this problem expedites the patients' return to normal activities following surgery and significantly increases their satisfaction. There are no condensed results that show the prevalence and contributing variables of postoperative nausea and vomiting in Africa. Thus, the purpose of this meta-analysis and comprehensive review was to ascertain the prevalence and contributing variables of postoperative nausea and vomiting in Africa. METHODS: Studies were retrieved from the PubMed, EMBASE, Cochrane Database, CINAHL, Scopus, Mednar, and Google Scholar databases using combinations of searching terms and Boolean operators. RESULTS: In Africa, the combined incidences of nausea 24.96 % (95% CI: 17.903-32.018), vomiting 23.655 % (95% CI: 17.542-29.769) and nausea with vomiting 15.27 % (95% CI: 9.118-21.424) . History of motion sickness (odds ratio [OR]: 3.19 (95% CI 1.08-9.42), CONCLUSION: Postoperative nausea and vomiting were more common in surgically treated African individuals. Clinical interventions are needed to prevent, diagnose, and treat postoperative nausea and vomiting (PONV), with a focus on patients who have experienced motion sickness, high-risk surgery, or PONV in the past. It is advisable to use whole intravenous anesthesia based on Propofol for surgery, if feasible.