Identification of

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Tác giả: Siyan Chen, Sheng Gao, Yanggang Hong, Chunyan Hua, Lingjie Kong, Yiming Lin, Jintao Mo, Hengrong Qian, Liangxing Wang, Wenqian Wang, Xinlei Wu, Yuanyuan Xie, Zhouhang Xing, Ting Zhang, Anzhe Zheng

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: New Zealand : Journal of inflammation research , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 724620

BACKGROUND: Systemic lupus erythematosus (SLE) is characterized by aberrant immune activation and disrupted iron metabolism, yet the molecular mediators that govern both processes remain unclear. This study aims to identify pivotal genes that modulate immune responses and iron metabolism, and to delineate their contributions to SLE pathogenesis. METHODS: Differentially expressed genes related to iron metabolism (IM-DEGs) were identified using datasets (GSE72326, GSE110169, GSE126307, and GSE50772) from the GEO database and the MSigDB. Functional enrichment analyses were performed on the iron metabolism related genes (IM-Genes). A weighted gene co-expression network analysis was constructed to identify hub genes, which were further refined as potential biomarkers using the least absolute shrinkage and selection operator method. The predictive value of these biomarkers was validated using receiver operating characteristic (ROC) curves and the nomogram. CIBERSORT was employed to evaluate immune cell infiltration in SLE. Additionally, the expression and function of RESULTS: Bioinformatics analyses identified 4 potential biomarkers: CONCLUSION: Our findings suggest that
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