Inactivation of multidrug-resistant bacteria using cold atmospheric-pressure plasma technology.

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Tác giả: Mengzhen Chen, Yan Chen, Chao Huang, Ye Lu, Xingxing Wang, Zhibiao Yang, Peihao Yu, Chen Zhang, Jian-Cang Zhou

Ngôn ngữ: eng

Ký hiệu phân loại: 153.1534 Memory and learning

Thông tin xuất bản: Switzerland : Frontiers in medicine , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 724680

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OBJECTIVE: This study aimed to investigate the impact of cold atmospheric-pressure plasma (CAP) on multidrug-resistant (MDR) bacteria on various surfaces under nosocomial circumstances and the underlying mechanism. METHOD: Four common MDR bacteria (carbapenem-resistant RESULT: In the CAP-producing device, most of the MDR bacteria were nearly inactivated after 2 h of CAP treatment. Under the simulated ward, CAP exerted an inactivating effect on MDR bacteria. Scanning electron microscopy revealed that the surface of MDR bacteria became blurred, the bodies ruptured and adhered to each other after CAP treatment. The cell walls were thinner as revealed by transmission electron microscopy. CONCLUSION: CAP could inactivate the most common MDR bacteria on nosocomial surfaces in simulation ward settings by destroying the structure of pathogens. Our data provided insights into the sterilization of MDR bacteria using CAP and suggested a novel in-hospital disinfection alternative.

1. Inactivation
2. Of
3. Multidrug

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