Impact of Radiometal Chelates on In Vivo Visualization of Immune Checkpoint Protein Using Radiolabeled Affibody Molecules.

• Tác giả: Ekaterina A Bezverkhniaia, Matilda Carlqvist, Fredrik Y Frejd, Anna Orlova, Maryam Oroujeni, Eleftherios Papalanis, Alia Hani Rosly, Vladimir Tolmachev, Anzhelika Vorobyeva
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : ACS pharmacology & translational science , 2025
• Bộ sưu tập: NCBI
• ID: 724698

Tóm tắt

The immune checkpoint protein B7-H3 (CD276) is overexpressed in various cancers and is an attractive target for the treatment of malignant tumors. Radionuclide molecular imaging of B7-H3 expression using engineered scaffold proteins such as Affibody molecules is a promising strategy for the selection of potential responders to B7-H3-targeted therapy. Feasibility of B7-H3 imaging was demonstrated using two