Monocyclic monoterpenoid ocimene (OC) was evaluated as a potential inhibitor of TLR4/NLRP3/GSDMD-driven pyroptosis, implicated in conditions such as chronic pain, inflammation, and gastric ulcers. This study investigated OC's protective effects against indomethacin (IND)-induced gastric ulcers, aiming to identify an analgesic and anti-inflammatory agent with enhanced gastric safety. OC's analgesic efficacy was demonstrated by reducing formalin-evoked paw licking, writhing provoked by acetic acid-induced and tail immersion reaction latencies in animal models. Anti-inflammatory effects were confirmed through reduced paw edema (formalin and carrageenan), along with