T-cell prolymphocytic leukemia, a case report and review of the literature.

• Tác giả: ADRIáN Alegre, Eva Arranz, Jimena Cannata-Ortiz, Samir Dalia, Luis Manuel GONZáLEZ-RODRíGUEZ, Luis Miguel JUáREZ-Salcedo, Maria JOSé LóPEZ DE LA Osa, Javier Loscertales, Javier Ortiz
• Ngôn ngữ: eng
• Ký hiệu phân loại: 133.594 Types or schools of astrology originating in or associated with a
• Thông tin xuất bản: United States : Oncology research , 2025
• Bộ sưu tập: NCBI
• ID: 724811

Tóm tắt

 T-prolymphocytic leukemia is a rare and aggressive hematological malignancy characterized by the clonal proliferation of mature lymphoid T-cells. The pathogenesis of T-PLL is closely linked to specific chromosomal abnormalities, primarily involving the proto-oncogene T-cell leukemia/lymphoma 1 gene family. Recent advancements in molecular profiling have identified additional genomic aberrations, including those affecting the Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathway. This case report presents a patient with T-prolymphocytic leukemia whose cytogenetic and molecular analysis revealed a t(X
 14)(q28
 q11.2) translocation and a