Hypozincemia Is Associated With Increased Tyrosine Levels, Low Handgrip Strength, Increased Incidence of HCC, and Liver Disease Progression-A Cross-Sectional Study.

• Tác giả: Tomoko Handa, Jun Inoue, Tomoo Kobayashi, Yasuhiro Kojima, Yutaka Kondo, Makoto Kurihara, Atsushi Masamune, Motoki Ohyauchi, Akihiro Saitou, Manabu Shiraki, Yu Tanaka, Mitsuru Yamakawa
• Ngôn ngữ: eng
• Ký hiệu phân loại: 781.649 +Rap
• Thông tin xuất bản: Australia : JGH open : an open access journal of gastroenterology and hepatology , 2025
• Bộ sưu tập: NCBI
• ID: 724820

Tóm tắt

 BACKGROUND: Serum zinc levels decrease in chronic liver disease (CLD), but their effects on liver reserve function, tyrosine, skeletal muscle mass, handgrip strength (HGS), and hepatocellular carcinoma (HCC) development remain poorly understood. METHODS: A retrospective, cross-sectional study was conducted on 516 CLD cases. Patients were divided into a low zinc group (<
  80 μg/dL) and a high zinc group (≥ 80 μg/dL). Serum zinc levels were analyzed with liver reserve function (assessed by modified albumin-bilirubin [mALBI] grade), tyrosine, branched-chain amino acid/tyrosine ratio (BTR), and HCC development. In 180 cases, the relationship between serum zinc levels and skeletal muscle characteristics, including sarcopenia and HGS, was investigated. RESULTS: Tyrosine levels increased significantly with mALBI grade progression. Patients in the low zinc group had higher tyrosine levels (76.9 vs. 67.2 μmol/L, CONCLUSION: Hypozincemia is linked to elevated tyrosine levels, reduced HGS, increased HCC incidence, and CLD progression.