Obesity promotes immunotherapy efficacy by up-regulating the glycolytic-mediated histone lactacylation modification of CD8+ T cells.

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Tác giả: Xing-Hao Ai, Dong-Min Shi, Xiao-Li Shi, Jing-Yuan Wang, Kai-Xuan Wang

Ngôn ngữ: eng

Ký hiệu phân loại: 373.236 Lower level

Thông tin xuất bản: Switzerland : Frontiers in pharmacology , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 725046

The response rate of immune checkpoint blockade (ICB) therapy for non-small-cell lung cancer (NSCLC) remains limited. Recent evidence suggests that obese cancer patients are more likely to benefit from ICB therapy, however, the specific mechanism needs further research. In this study, we found that anti-PD-1 therapy was more effective in obese NSCLC patients compared to normal weight patients and this was verified in mouse NSCLC model. Further bioinformatics analysis indicated that the glycolytic metabolism was markedly elevated in obese NSCLC patients.
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