INTRODUCTION: Increasing evidence indicates that cellular senescence is a significant risk factor for atherosclerosis (AS). METHODS: In the present study, we used an apolipoprotein E knockout (ApoE RESULTS: We observed that sodium nitrate decreased the Oil Red O-positive area, reduced the serum cholesterol (CHO) and triglyceride (TG) concentrations, and relieved inflammatory reactions in ApoE DISCUSSION: These findings might lead to the introduction of a new therapy for senescence-related diseases in the future.