OBJECTIVE: To describe the burden of calcium channel blocker (CCB) overdose at a tertiary intensive care unit (ICU). DESIGN AND SETTING: Retrospective study of patients admitted to the ICU with CCB overdose from 2020 to 2022. PARTICIPANTS: Adult participants with clinically confirmed CCB overdose. MAIN OUTCOME: Admission frequency, management strategies, and patient outcomes. RESULTS: A total of 1719 ICU admissions over the study period, 24 (1.4%) had CCB overdose with a case fatality rate of 12.5% (3/24). Interventions included mechanical ventilation (MV) (71%), vasopressors (92%), high-dose insulin euglycemic therapy (HIET) (71%), calcium (42%), methylene blue (4%), and fluid therapy (100%). Thirteen patients (54%) received hemoadsorption therapy (HA), and eleven received standard of care (SoC) based on current guidelines. The resin hemoadsorption group had a higher SAPS II score ( CONCLUSION: Calcium channel blocker overdose is an important and life-threatening cause of toxicology admissions in the ICU. Modern resin HA may contribute to improved hemodynamic stability providing a safe and important rescue therapy in cases with refractory shock. Well-designed studies are required to confirm its role in enhancing drug clearance thereby improving the hemodynamic state and clinical outcomes. HOW TO CITE THIS ARTICLE: Omar S, Shukla V, Khan AB, Dangor Z. Hemoadsorption Therapy for Calcium Channel Blocker Overdose at a Tertiary-level Intensive Care Unit: A Retrospective Study. Indian J Crit Care Med 2025
29(2):130-136.