Microstructural diffusion MRI for differentiation of breast tumors and prediction of prognostic factors in breast cancer.

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Tác giả: Jingliang Cheng, Ying Hu, Ying Li, Liangjie Lin, Anfei Wang, Ruhua Wang, Xiaoyan Wang, Kun Zhang, Wenhua Zhang, Yan Zhang, Yong Zhang

Ngôn ngữ: eng

Ký hiệu phân loại: 553.674 Mica

Thông tin xuất bản: Switzerland : Frontiers in oncology , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 725110

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PURPOSE: This study aims to investigate the feasibility of cellular microstructural mapping by the diffusion MRI (IMPULSED, imaging microstructural parameters using limited spectrally edited diffusion) of breast tumors, and further to evaluate whether the MRI-derived microstructural features is associated with the prognostic factors in breast cancer. MATERIALS AND METHODS: This prospective study collected 232 patients with suspected breast tumors from March to August 2023. The IMPULSED MRI scan included acquisitions of diffusion MRI using both pulsed (PGSE) and oscillating (OGSE) gradient spin echo with the oscillating frequencies up to 33 Hz. The OGSE and PGSE data were fitted by the IMPUSLED method using a two-compartment model to estimate mean cell diameter ( RESULTS: 213 patients were finally included and divided into malignant (n=130) and benign (n=83) groups according to the histopathological results. The CONCLUSION: The IMPULSED method demonstrates promise for characterizing cellular microstructural features in breast tumors, which may be helpful for prognostic risk evaluation in breast cancer.

1. Microstructural
2. Diffusion
3. Mri

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