INTRODUCTION AND IMPORTANCE: Gastric plication is a bariatric procedure that involves suture imbrication of the greater curvature to restrict the volume of the stomach. Although gastroduodenal intussusception is a complication that surgeons may encounter in their practice, it is rarely reported or published, which limits the available knowledge in medical literature. CASE PRESENTATION: The authors report two female patients who developed gastroduodenal intussusception following gastric plication procedure, requiring surgical treatment. Both patients presented with non-specific, atypical abdominal pain several months after gastric plication. Both patients required surgical intervention, which included manual reduction of the plication followed by subtotal gastrectomy en bloc with Roux-en-Y reconstruction. In the second case, an omega Braun anastomosis was performed, and a jejunostomy was created after the anastomosis in both patients. CLINICAL DISCUSSION: The optimal management of gastroduodenal intussusception remains challenging due to the lack of reported cases and the technical difficulties that surgeons may face. CONCLUSION: It appears that we will encounter some problems and complications in the present time and the near future, including some that are rare in bariatric surgery, particularly those procedures that have fallen out of favor, such as gastric plication surgery.