BACKGROUND: The prevalence of total dental caries (untreated and treated) in primary or permanent teeth increases with age, going from 21.4, 50.5, and 53.8% among ages 2-5, 6-11, and 12-19, respectively. Dental caries is a dynamic process of demineralization and remineralization, and the use of various topical and systemic fluoride- and nonfluoride-based remineralizing agents can help replenish lost ions, promoting remineralization and further decreasing the prevalence of caries. OBJECTIVES: The aim of this study is to formulate the grape seed extract-containing tooth mousse and to compare its physiochemical properties with the commercially available GC Tooth Mousse. MATERIALS AND METHODS: The methodology involves formulating a tooth mousse incorporating grape seed extract and conducting physicochemical evaluations to compare its properties with those of the commercially available GC Tooth Mousse. RESULTS: Physicochemical parameters of grape seed extract-containing tooth mousse are similar to the gold standard GC Tooth Mousse. Along with that, the slight acidity of the grape seed mousse supports the remineralization process. CONCLUSION: The study highlights that the grape seed extract-containing mousse offers a promising alternative to the marketed GC Tooth Mousse. HOW TO CITE THIS ARTICLE: Gujarathi A, Shah P, Jajoo S,