Treatment of Extraosseous Giant Cell Tumor of Bone and Calcitriol-Mediated Hypercalcemia With Denosumab in Paget Disease.

• Tác giả: Clemens Bergwitz, Oyunbileg Magvanjav
• Ngôn ngữ: eng
• Ký hiệu phân loại: 616.909 Historical, geographic, persons treatment of communicable diseases
• Thông tin xuất bản: England : JCEM case reports , 2025
• Bộ sưu tập: NCBI
• ID: 725457

Tóm tắt

 Extraosseous giant cell tumor of bone (GCTB) associated with Paget disease of bone (PDB) is rare. We report a patient aged in their 70s with polyostotic PDB involving the skull, spine, and pelvis, previously treated with bisphosphonates, who presented with symptomatic hypercalcemia (calcium 14.8 mg/dL [3.7 mmol/L]
  reference range [RR], 8.6-10.5 mg/dL [2.1-2.6 mmol/L]), kidney injury (creatinine 2.6 mg/dL [230 μmol/L]
  RR, 0.4-1.1 mg/dL [35-97 μmol/L]), and a 17.5 cm pelvic mass. Testing showed elevated calcitriol or 1,25-dihydroxyvitamin D (1,25(OH)