Skin aging is a multifaceted biological process influenced by both intrinsic and extrinsic factors. It involves changes at the tissue, cellular, and molecular levels. Recently, clinical trials have provided growing evidence across various aspects of skin aging. This study provides a thorough analysis of scientific publications on clinical trials related to skin aging. It includes publications indexed in the Scopus database between 2005 and 2024, retrieved using a wide array of pertinent keywords. Following this, network analysis and visualization were performed with VOSviewer (v. 1.6.20) to map research trends and pinpoint emerging research hotspots. From 2005 to 2024, 550 publications investigated the relationship between clinical trials and skin aging. Over the past two decades, the number of publications in this field has increased significantly (R