OBJECTIVES: To develop a nomogram that assists in selecting nasopharyngeal carcinoma (NPC) patients suitable for induction chemotherapy. MATERIALS AND METHODS: This retrospective study included NPC patients who underwent multiphasic contrast‑enhanced DECT (comprising non-contrast, arterial, and venous phase scanning) between May 2019 and December 2023. The relationships between quantitative DECT-derived parameters and treatment response to induction chemotherapy were analyzed using logistic regression analysis. The predictive performance of a nomogram integrating key predictors was assessed using the area under the receiver operating characteristic curve (AUC). RESULTS: A total of 294 patients (median age, 53 years
interquartile range, 46-59 years
224 men) were included. Among these, 215 were responders and 79 were non-responders. The normalized iodine concentration in the arterial phase (nIC CONCLUSIONS: We developed a comprehensive nomogram to predict treatment response to induction chemotherapy by integrating nIC KEY POINTS: Question To date, no reliable method has been established to predict the efficacy of induction chemotherapy for nasopharyngeal carcinoma prior to treatment. Findings nIC