INTRODUCTION: Cleft lip and/or cleft palate (CLP) is among the most prevalent congenital anomalies, with significant long-term impacts on oral health and psychosocial well-being. Despite multiple surgeries aimed at enhancing both functionality and aesthetics, individuals' perceptions of quality of life (QoL) can vary widely. This study sought to examine the long-term effects of corrective surgeries for orofacial clefts (OFC) on oral health-related quality of life (OHRQoL) in South India, comparing outcomes between treated CLP patients and apparently healthy individuals. MATERIALS AND METHODS: The study included 200 treated CLP patients and 200 healthy controls. Oral Health Impact Profile (OHIP) -14 scale was utilized to assess OHRQoL. RESULTS: Data analysis compared OHRQoL between the study group and controls. Treated CLP patients exhibited significantly poorer OHRQoL compared to healthy controls across various parameters. While surgical intervention improved certain aspects, challenges in pronunciation, taste sensation, discomfort, and psychological strain persisted. Internal consistency of the OHIP-14 questionnaire was excellent. CONCLUSIONS: The findings emphasize the need for comprehensive care beyond surgery, including psychological support, to address the enduring effects on OHRQoL among CLP patients. Further research is warranted to explore long-term effects and cultural considerations for better supporting this patient population.