Towards fully automatized [177Lu]Lu-PSMA personalized dosimetry based on 360° CZT whole-body SPECT/CT: a proof-of-concept.

• Tác giả: Pierre Decazes, Arnaud Dieudonné, Arthur Dumouchel, Agathe Edet-Sanson, Sébastien Hapdey, Romain Modzelewski, Solène Perret, Aya Terro, David Tonnelet, Pierre Vera
• Ngôn ngữ: eng
• Ký hiệu phân loại: 261.834 Christian attitudes toward social groups
• Thông tin xuất bản: Germany : EJNMMI physics , 2025
• Bộ sưu tập: NCBI
• ID: 725770

Tóm tắt

BACKGROUND: The advent of 360° CZT gamma-cameras allows to conceive personalised dosimetry studies from whole-body SPECT/CT data. We aimed to demonstrate the proof-of-concept of an automated personalized dosimetry pipeline for [ METHODS: The organ segmentation is based on a nnU-Net framework that was trained to allow for the segmentation of 23 organs and structures over all the body. The method implemented to model the energy deposition is the collapsed-cone-superposition (CCS) taking into account non-uniform activity and density distributions. Ten patients with metastatic castration resistant prostate cancer treated [ RESULTS: The median (IQR) calculation time with SimpleDose (SD), for segmentation, computation of dose-rates and descriptive statistics was 161 (23) seconds at a resolution of 2.46 × 2.46 × 2.46 mm CONCLUSION: The SimpleDose platform demonstrated its capability to compute organ-absorbed-dose rates in a simple and fast manner with close results to the standard MIRD approach for soft-tissues organs. SimpleDose is freely available for demonstration purpose as a Software as a Service (SaaS) at https://oncometer3d.com .