Development of a CT-less SPECT Acquisition Protocol for Kidney Dosimetry in

• Tác giả: Benjamin Bockisch, Daniel Groener, Frank Grünwald, Christian Happel, Britta Leonhäuser, Amir Sabet, Larissa Völler
• Ngôn ngữ: eng
• Ký hiệu phân loại: 338.9 Economic development and growth
• Thông tin xuất bản: United States : Molecular imaging and biology , 2025
• Bộ sưu tập: NCBI
• ID: 725811
• Chủ đề: 1. Development; 2. Of; 3. A

Tóm tắt

PURPOSE: Targeted radioligand therapy of metastatic castration-resistant prostate cancer (mCRPC) with PROCEDURES: A dedicated torso phantom with kidneys filled with a solution of RESULTS: Volumes of interest of the kidneys were drawn in the three sequential SPECT-images to calculate intra-renal effective half-life. Absolute quantification of activity in the kidneys was accomplished obtaining a patient individual sensitivity based on the individual attenuation in the patient. Kidney dose was then calculated applying a bi-exponential time activity curve in Microsoft EXCEL. Mean kidney dose per administered activity was 0.54 (± 0.26) Gy/GBq. CONCLUSIONS: With the presented procedure a reliable kidney dosimetry is possible without the use of SPECT/CT. Facilities without SPECT/CT are therefore able to perform an adequate kidney dosimetry without additional radiation exposure for the patient.