INTRODUCTION: This study investigated the mental health status of caregivers of children with asthma and analyzed the associated influencing factors. METHOD: We recruited 337 children with asthma and their caregivers. Student's RESULTS: Caregivers' mental health scores were 2.52 ± 2.33. Statistical analysis revealed a significant difference ( DISCUSSION: Caregivers of children with asthma exhibited notable levels of mental well-being, albeit accompanied by concurrent experiences of anxiety and depression. In addition to their primary responsibilities of treating and caring for children, medical professionals should prioritize the mental health of caregivers and promptly offer appropriate guidance and support. (PsycInfo Database Record (c) 2025 APA, all rights reserved).