We examined differences and similarities between groups sampled from the Mediterranean region in social orientation, cognitive style, self-construal, and honor, face, dignity values, and concerns using a large battery of tasks and measures. We did this by conducting secondary data set analyses focusing on comparisons between nine pairs of samples recruited from the Mediterranean region (Spain, Italy, Greece, Turkey, Cyprus [Greek and Turkish Cypriot communities], Lebanon [Muslim Lebanese and Christian Lebanese], Egypt) that have overlapping and divergent features in terms of religious, ethnic, national, and linguistic factors as well as various physical and socioecological characteristics. Across 38 different psychological characteristics, comparisons between Turkish and Turkish Cypriot samples and between Christian and Muslim samples from Lebanon revealed that they were most similar to each other. In contrast, Greek and Turkish samples were the least similar. Our analyses of intercorrelations between variables, variability, and size of differences provide additional insights into the within-region variation in social orientation, cognitive style, self-construal indicators, as well as honor, face, and dignity values and concerns. Our research contributes to the growing literature on regional variation of psychological processes while raising important pointers for the role of background and socioecological characteristics in cultural group similarities and differences. (PsycInfo Database Record (c) 2025 APA, all rights reserved).