Neuroprotective effects of SGLT2 inhibitors empagliflozin and dapagliflozin on Aβ

• Tác giả: Mehdi Alami, Hicham Berrougui, Ton Bunt, Alan A Cohen, Tamas Fulop, Denis Gris, Nabil Hajji, Katsuiku Hirokawa, Abdelouahed Khalil, Guy Lacombe, Benoit Laurent, Charles Ramassamy, Olaf van Tellingen, Jacek M Wikowski, Echarki Zerif
• Ngôn ngữ: eng
• Ký hiệu phân loại: 152.1822 Sensory perception
• Thông tin xuất bản: United States : Journal of Alzheimer's disease : JAD , 2025
• Bộ sưu tập: NCBI
• ID: 726037

Tóm tắt

BackgroundAlzheimer's disease (AD) is a chronic brain degenerative disease that leads to dementia.ObjectiveThe aim of the present study is to investigate the neuroprotective impact of sodium-glucose cotransporter-2 inhibitors (SGLT2i) (empagliflozin and dapagliflozin) on tau phosphorylation, oxidative stress, and neuroinflammation.MethodsWe used MTT (3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide) assay, annexin-V-FITC kit, and DCFH-DA (dichloro-dihydro-fluorescein diacetate) to respectively evaluate the effect of the SGLT2i (empagliflozin and dapagliflozin) on amyloid-β (Aβ)