Epithelial polarization by the planar cell polarity complex is exclusively non-cell autonomous.

 0 Người đánh giá. Xếp hạng trung bình 0

Tác giả: Lena P Basta, Danelle Devenport, Bradley W Joyce, Eszter Posfai

Ngôn ngữ: eng

Ký hiệu phân loại: 599.26 *Peramelina (Bandicoots)

Thông tin xuất bản: United States : Science (New York, N.Y.) , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 726141

For cells to polarize collectively along a tissue plane, asymmetrically localized planar cell polarity (PCP) complexes must form intercellular contacts between neighboring cells. Yet, it is unknown whether asymmetric segregation of PCP complexes requires cell-cell contact, or if cell autonomous, antagonistic interactions are sufficient for polarization. To test this, we generated mouse chimeras consisting of dual PCP-reporter cells mixed with unlabeled cells that cannot form PCP bridges. In the absence of intercellular interactions, PCP proteins failed to polarize cell autonomously. Rather, PCP-mediated contacts along single cell-cell interfaces were sufficient to sort PCP components to opposite sides of the junction, independent of junction orientation. Thus, intercellular binding of PCP complexes is the critical step that initiates sorting of opposing PCP complexes to generate asymmetry.
Tạo bộ sưu tập với mã QR

THƯ VIỆN - TRƯỜNG ĐẠI HỌC CÔNG NGHỆ TP.HCM

ĐT: (028) 36225755 | Email: tt.thuvien@hutech.edu.vn

Copyright @2024 THƯ VIỆN HUTECH