Discovery of Novel Sulfonylurea NLRP3 Inflammasome Inhibitor for the Treatment of Multiple Inflammatory Diseases.

• Tác giả: Ying Hong, Cuina Li, Jiyuan Li, Hong Liu, Yiting Liu, Jinyu Ma, Jiang Wang, Qinxue Wang, Qiannan Xiao, Cen Xie, Xiong Xie
• Ngôn ngữ: eng
• Ký hiệu phân loại: 809.008 History and description with respect to kinds of persons
• Thông tin xuất bản: United States : Journal of medicinal chemistry , 2025
• Bộ sưu tập: NCBI
• ID: 726143

Tóm tắt

NLRP3 inflammasome is critical in innate immunity and inflammatory responses. A series of novel sulfonylurea-based NLRP3 inflammasome inhibitors was designed and synthesized. Notably, compound